81 Results for "

Sophora tomentosa L.

" in MedChemExpress (MCE) Product Catalog:
Products (81)

81 Results for "Sophora tomentosa L." in MCE Product Catalog:

20
Oxymatrine
Oxymatrine
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20 Publications Verification
Cat. No.: HY-N0158
CAS No.: 16837-52-8
Category:  

Infection Alkaloids Piperidine Alkaloids Leguminosae Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology

Target:  

TGF-beta/Smad Apoptosis

Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .
18
Matrine
Matrine
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18 Cited Publications
Cat. No.: HY-N0164
CAS No.: 519-02-8
Synonyms: Matridin-15-one; Vegard; α-Matrine
Category:  

Alkaloids Piperidine Alkaloids Leguminosae Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology Biological Pesticide Research Cancer Agricultural Research

Target:  

PINK1/Parkin Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis

Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .
7
Aloperine
Aloperine
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7 Cited Publications
Cat. No.: HY-13516
CAS No.: 56293-29-9
Purity:  ≥98.0%
Category:  

Infection Alkaloids Piperidine Alkaloids Leguminosae Sophora alopecuroides L Plants Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Autophagy Filovirus HIV

Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties . Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China . Aloperine induces apoptosis and autophagy in HL-60 cells .
6
Sophoridine
Sophoridine
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6 Cited Publications
Cat. No.: HY-N1373
CAS No.: 6882-68-4
Category:  

Alkaloids Leguminosae Pyridine Alkaloids Plants Sophora flavescens Aiton Disease Research Fields Cancer

Target:  

Apoptosis

Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity .
6
Oxysophocarpine
Oxysophocarpine
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6 Cited Publications
Cat. No.: HY-N0746
CAS No.: 26904-64-3
Category:  

Alkaloids Piperidine Alkaloids Leguminosae Sophora alopecuroides L Plants Disease Research Fields Cancer

Target:  

Others

Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides.?Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the?growth?and?metastasis?of ?oral?squamous?cell?carcinoma?(OSCC) .
4
Sophoricoside
Sophoricoside
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4 Cited Publications
Cat. No.: HY-N0423
CAS No.: 152-95-4
Category:  

Flavonoids Leguminosae Sophora japonica (L.) Schott Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Isoflavones

Target:  

Others

Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.
4
Kushenol A
Kushenol A
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4 Cited Publications
Cat. No.: HY-N2278
CAS No.: 99217-63-7
Synonyms: Leachianone E
Category:  

Flavonoids Leguminosae Flavonones Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Cancer

Target:  

Tyrosinase Glycosidase

Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively . Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging .
3
Sophoraflavanone G
Sophoraflavanone G
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3 Cited Publications
Cat. No.: HY-N1231
CAS No.: 97938-30-2
Synonyms: Kushenol F
Category:  

Flavonoids Leguminosae Flavonones Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Cancer

Target:  

Apoptosis

Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.? Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways .
1
Kushenol E
Kushenol E
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1 Cited Publications
Cat. No.: HY-N2463
CAS No.: 99119-72-9
Category:  

Flavonoids Leguminosae Flavonones Phenols Polyphenols  Moghania philippinensis (Merr. Et Rolfe) L. Plants Disease Research Fields Cancer

Target:  

Indoleamine 2,3-Dioxygenase (IDO)

Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7 µM and a Ki of 9.5 µM, has anti-tumor activity .
1
Sophoramine
Sophoramine
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1 Cited Publications
Cat. No.: HY-N3198A
CAS No.: 6882-66-2
Synonyms: (-)-Sophoramine
Category:  

Alkaloids Leguminosae Other Diseases Pyridine Alkaloids Plants Sophora flavescens Aiton Disease Research Fields

Target:  

Adrenergic Receptor

Sophoramine ((-)-Sophoramine) is a prejunctional α2-adrenoceptor inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias .
1
Kushenol I
Kushenol I
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1 Cited Publications
Cat. No.: HY-N2286
CAS No.: 99119-69-4
Category:  

Flavanonols Flavonoids Leguminosae Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology

Target:  

Others

Kushenol I is a natural compound isolated from the roots of Sophora flavescens .
Trifolirhizin
Trifolirhizin
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Cat. No.: HY-N0616
CAS No.: 6807-83-6
Category:  

Flavonoids Leguminosae Plants Trifolium pratense Linn. Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology Other Flavonoids Cancer

Target:  

Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB

Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC50 value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .
(-​)​-Maackiain
(-​)​-Maackiain
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Cat. No.: HY-N6051
CAS No.: 2035-15-6
Category:  

Infection Monophenols Leguminosae Terpenoids Phenols Diterpenoids Plants Sophora flavescens Aiton Disease Research Fields

Target:  

Fungal NOD-like Receptor (NLR) NF-κB

(-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .
Rhodomyrtone
Rhodomyrtone
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Cat. No.: HY-N13668
CAS No.: 468757-69-9
Category:  

Myrtaceae Phenols Polyphenols Rhodomyrtus tomentosa Plants

Target:  

Antibiotic Bacterial

Rhodomyrtone is an antibiotic that can be found in the leaves of Rhodomyrtus tomentosa. Rhodomyrtone kills Gram-positive bacterial cells without causing bacteriolysis. Rhodomyrtone exhibits activity against a variety of Gram-positive bacteria, including Bacillus cereus, Bacillus subtilis, Enterococcus faecalis, Staphylococcus epidermidis, Streptococcus gordonii, Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus salivarius. Rhodomyrtone is applicable to studies related to bacterial infections .
Mitraphylline
Mitraphylline
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Cat. No.: HY-N6946
CAS No.: 509-80-8
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Iridoids Terpenoids Rubiaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Interleukin Related

Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo .
Paulownin
Paulownin
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Cat. No.: HY-N2324
CAS No.: 13040-46-5
Synonyms: (+)-Paulownin
Category:  

other families Lignans Metabolic Disease Phenylpropanoids Plants Disease Research Fields

Target:  

Others

Paulownin, a component of wood of Paulownia tomentosa Steud, is a constituent of medicinal plants .
Oxysophoridine
Oxysophoridine
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Cat. No.: HY-N1402
CAS No.: 54809-74-4
Synonyms: Sophoridine N-oxide
Category:  

Alkaloids other families Pyridine Alkaloids Plants Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis

Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects .
Diplacone
Diplacone
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Cat. No.: HY-N16129
CAS No.: 73676-38-7
Synonyms: Nymphaeol A; Propolin C
Category:  

Flavonoids Paulownia tomentosa (Thunb.) Steud. Flavones Scrophulariaceae Plants

Target:  

COX Reactive Oxygen Species (ROS) Calcium Channel Ferroptosis Mitochondrial Metabolism MMP

Diplacone is an orally active geranyl flavanone. It is isolated from the fruits of Paulownia tomentosa. Diplacone reduces COX-2 levels and increases the pro-MMP2/MMP2 ratio. It induces ferroptosis-mediated cell death. Diplacone enhances mitochondrial Ca 2+ influx and ROS production. It possesses anti-inflammatory and free radical-scavenging activities. Diplacone can be used in research related to ulcerative colitis and non-small cell lung cancer .
(2S)-2'-Methoxykurarinone
(2S)-2'-Methoxykurarinone
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Cat. No.: HY-N1746
CAS No.: 270249-38-2
Synonyms: 2'-O-Methylkurarinone
Category:  

Flavonoids Leguminosae Flavonones Metabolic Disease Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology

Target:  

RANKL/RANK

(2S)-2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells .
Melitidin
Melitidin
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Cat. No.: HY-N10620
CAS No.: 1162664-58-5
Category:  

Flavonoids Citrus maxima (Burm.) Merr. Flavones Rutaceae Plants

Target:  

Others

Melitidin is a flavanone glycoside, that can be isolated from Citrus grandis 'Tomentosa'. Melitidin shows a good antitussive effect on cough induced by citric acid in Guinea pig .
Assay Types